Publications

Huang Q, Wang Y, Farias K, Zeng X, Chen Q, Cheng H, Gross SS, Geri J, Sauve AA, Yang Y.  2025.  NAD⁺ Replenishment Mitigates Cardiomyocyte Senescence and Corrects Heart Failure with Preserved Ejection Fraction in Aged Mice.. bioRxiv.

Zeng X, Wang Y, Farias K, Rappa A, Darko C, Sauve A, Huang Q, Alonso LC, Yang Y.  2025.  NRH, a potent NAD+ enhancer, improves glucose homeostasis and lipid metabolism in diet-induced obese mice through an active adenosine kinase pathway.. Metabolism. 164:156110.

Sauve AA, Wang Q, Zhang N, Kang S, Rathmann A, Yang Y.  2023.  Triple-Isotope Tracing for Pathway Discernment of NMN-Induced NAD+ Biosynthesis in Whole Mice.. Int J Mol Sci. 24(13)

Yang Y, Sauve AA.  2021.  Assays for Determination of Cellular and Mitochondrial NAD+ and NADH Content.. Methods Mol Biol. 2310:271-285.

Yang Y, Zhang N, Zhang G, Sauve AA.  2020.  NRH salvage and conversion to NAD+ requires NRH kinase activity by adenosine kinase.. Nat Metab. 2(4):364-379.

Yang Y, Mohammed FSultana, Zhang N, Sauve AA.  2019.  Dihydronicotinamide riboside is a potent NAD+ concentration enhancer in vitro and in vivo.. J Biol Chem. 294(23):9295-9307.

Gariani K, Menzies KJ, Ryu D, Wegner CJ, Wang X, Ropelle ER, Moullan N, Zhang H, Perino A, Lemos V et al..  2016.  Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice.. Hepatology. 63(4):1190-204.

Yang Y, Sauve AA.  2016.  NAD(+) metabolism: Bioenergetics, signaling and manipulation for therapy.. Biochim Biophys Acta. 1864(12):1787-1800.